Screening and diagnosis

Explore NCCN Guidelines® for lung cancer screening in select high-risk patients, the benefits of early screening with low-dose CT, and prognosis by stage of disease.


Current NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) recommend lung cancer screening in select High-Risk patients1

In 2011, approximately 94 million current or former smokers were considered to be at elevated risk for lung cancer.2

References:1. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening v3.2017. © National Comprehensive Cancer Network, Inc 2016.All rights reserved. Accessed June 14, 2016. To view the most recent and complete version of the guideline, go online to NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®, NCCN GUIDELINES®, and all other NCCN Content are trademarks owned by the National Comprehensive Cancer Network, Inc. 2. The National Lung Screening Trial Research Team. N Engl J Med. 2011;365(5):395-409.


Earlier Screening With Low-dose CT Reduces Mortality From Lung Cancer 1

The National Lung Cancer Screening Trial randomized 53,454 adults at high risk for lung cancer to compare mortality with annual screening of either low-dose CT or chest radiography.

From The New England Journal of Medicine, The National Lung Screening Trial Research Team, Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening. Vol 365, Page 405. Copyright  © (2011) Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.

  • More adenocarcinoma and squamous cell carcinoma were detected at an earlier stage (stage I) with low-dose CT (computed tomography) screening, compared with single-view posteroanterior chest x-ray screening1
  • Screening high-risk patients with low-dose CT represents a relative reduction in the risk of mortality from lung cancer by 20%1

Reference: 1. The National Lung Screening Trial Research Team. N Engl J Med. 2011;365(5):395-409.


NSCLC5-Year Survival Decreases With Advanced Stage of Disease at Diagnosis1,b


Stage at diagnosis

  • Localized: confined to primary site
  • Regional: spread to regional lymph nodes
  • Distant: cancer has metastasized

aIncludes lung and bronchus.
bBased on registry data of cancer diagnosed 2005-2011, all races, both sexes.

Reference: 1. National Cancer Institute. SEER stat fact sheets: lung and  bronchus cancer. Accessed March 31,2015.

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